Cancer Genomics Proteomics Table of Contents for May-June 2017; Vol. 14, No. 3

Cancer Genomics & Proteomics
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Cancer Genomics & Proteomics
May-June 2017; 14 (3)

Review: Long Non-coding RNAs and their Role in Metastasis
ULRICH H. WEIDLE, FABIAN BIRZELE, GWEN KOLLMORGEN, and RÜDIGER RÜGER
Cancer Genomics Proteomics May-June 2017 14 (3) 143-160 OPEN ACCESS ARTICLE FREE
http://cgp.iiarjournals.org/content/14/3/143.abstract
Mining Exosomal Genes for Pancreatic Cancer Targets
AMY MAKLER and RAMASWAMY NARAYANAN
Cancer Genomics Proteomics May-June 2017 14 (3) 161-172 OPEN ACCESS ARTICLE FREE
http://cgp.iiarjournals.org/content/14/3/161.abstract
Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA)
RAFFAELE PALMIROTTA, DOMENICA LOVERO, ERICA SILVESTRIS, CLAUDIA FELICI, DAVIDE QUARESMINI, PAOLA CAFFORIO, and FRANCO SILVESTRIS
Cancer Genomics Proteomics May-June 2017 14 (3) 173-179 OPEN ACCESS ARTICLE FREE
http://cgp.iiarjournals.org/content/14/3/173.abstract
Prognostic Evaluation of Epidermal Growth Factor Receptor (EGFR) Genotype and Phenotype Parameters in Triple-negative Breast Cancers
SOFIA LEVVA, VASSILIKI KOTOULA, IOANNIS KOSTOPOULOS, KYRIAKI MANOUSOU, CHRISTOS PAPADIMITRIOU, KYRIAKI PAPADOPOULOU, SOTIRIS LAKIS, KYRIAKOS KOUKOULIAS, VASILIOS KARAVASILIS, GEORGE PENTHEROUDAKIS, EUFEMIA BALASSI, FLORA ZAGOURI, IOANNIS G. KAKLAMANOS, DIMITRIOS PECTASIDES, EVANGELIA RAZIS, GERASIMOS ARAVANTINOS, PAVLOS PAPAKOSTAS, DIMITRIOS BAFALOUKOS, GRIGORIOS RALLIS, HELEN GOGAS, and GEORGE FOUNTZILAS
Cancer Genomics Proteomics May-June 2017 14 (3) 181-195 OPEN ACCESS ARTICLE FREE
http://cgp.iiarjournals.org/content/14/3/181.abstract
Proteomics Analysis of Tissue Samples Reveals Changes in Mitochondrial Protein Levels in Parathyroid Hyperplasia over Adenoma
GURLER AKPINAR, MURAT KASAP, NUH ZAFER CANTURK, MEHIN ZULFIGAROVA, EYLÜL ECE ISLEK, SERTAC ATA GULER, TURGAY SIMSEK, and ZEYNEP CANTURK
Cancer Genomics Proteomics May-June 2017 14 (3) 197-211 OPEN ACCESS ARTICLE FREE
http://cgp.iiarjournals.org/content/14/3/197.abstract

Cystic tumour of the atrioventricular node: treatment dilemma

An asymptomatic 18-year-old black woman was found to have an incidental finding of third-degree atrioventricular (AV) block on a routine ECG. 2-Dimensional transthoracic echocardiography showed a heterogeneous mass in the region of the peri-membranous septum in the AV node area. A cardiac MRI showed a well-defined cystic mass arising from the right side of the interatrial septal wall. An MRI compatible permanent pacemaker was implanted with plans to monitor the tumour with non-invasive imaging. Cystic tumour of the AV node is a rare primary cardiac tumour. It is known as the smallest and most common primary cardiac tumour that can cause sudden death. All previous six cases of living patients with cystic tumour of the AV node reported in the literature were females and symptomatic. We present a rare case of a patient with cystic tumour of the AV node, and we highlight the treatment dilemmas for this condition.

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Intraductal oncocytic papillary neoplasm: a benign hepatic cystic neoplasm

A 61-year-old Asian man presented with severe right upper quadrant pain which had been worsening for several months. Laboratory results indicated elevated aspartate aminotransferase and alanine aminotransferase. The subsequent ultrasound, CT and MRI showed a large cystic mass with solid components and severe intrahepatic and extrahepatic biliary ductal dilatation. The mass was resected and pathology showed a well-demarcated mucinous cystic lesion with polygonal cells containing ovoid nuclei and abundant pink oncocytic cytoplasm. These findings are characteristic of intraductal oncocytic papillary neoplasm (IOPN), a rare subtype of intraductal papillary neoplasm of the liver. IOPN occurs most frequently in the Asian regions endemic to clonorchiasis and hepatolithiasis; however, cases have been reported in the Western world as well. Patients with IOPN are male or female and typically middle-aged. Treatment is typically resection. Prognosis is favourable and recurrence is rare. The 5-year survival rate is upwards of 80%.

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Mechanical CPR in a child: can one size fit all?

This case report describes the successful resuscitation of an 11-year-old boy who suffered out-of-hospital cardiac arrest (OHCA) using mechanical cardiopulmonary resuscitation (CPR) by adapting the Lund University Cardiopulmonary Assist System (LUCAS)2 Device by rolling a blanket under the patient’s back to increase his chest height, thus allowing the LUCAS device to administer compliant CPR.

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Unusual presentation for a tailgut cyst

A 67-year-old man with a slow-growing, asymptomatic perianal lesion was presented to the colorectal clinic. Physical examination and radiological investigation were suggestive of an externally prolapsing colonic polyp. However, intraoperative findings of a cystic lesion containing a thick brown substance questioned the initial diagnosis. After complete surgical resection of the encapsulated lesion, histological examination revealed a tailgut cyst (cystic hamartoma). These uncommon lesions originate from an embryological remnant of the hindgut. They are generally benign but may have extremely rare malignant potential which warrants complete surgical resection. Throughout the literature, they are described to present with various symptoms and may be found in several anatomical locations, most commonly within the retrorectal space. In very rare instances, with only two other documented cases, they can be found externally at the anorectal junction. Although very rare, an anal tailgut cyst should be taken into account in differential diagnosis.

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Severe vincristine-induced polyneuropathy in a teenager with anaplastic medulloblastoma and undiagnosed Charcot-Marie-Tooth disease

Severe neuropathy is a known adverse effect of vincristine in patients with Charcot-Marie-Tooth disease (CMT). We present the case of a 16-year-old girl with anaplastic medulloblastoma treated with gross total resection and high-dose craniospinal radiation with adjuvant vincristine chemotherapy who developed acute-onset severe quadriplegia and vocal cord paralysis. Vincristine and radiation therapy were discontinued. Although her neuropathy slowly improved over several weeks, she developed metastatic extraneural medulloblastoma and died 5 months after diagnosis. Subsequent genetic testing revealed previously asymptomatic and undiagnosed CMT1A. Our case highlights the importance of early recognition of acute vincristine neurotoxicity that should raise suspicion of an underlying hereditary neuropathy.

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