Correspondence Carbapenem-resistant and colistin-resistant co-producing NDM-9 and MCR-1

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The emergence of plasmid-mediated colistin resistance gene mcr-1 raised great concern that the world was on the cusp of the post-antibiotic era.1,2 Polymyxins, including colistin, are the last-resort antibiotics to treat serious infections caused by carbapenem-resistant Enterobacteriaceae.3 Here, we report a carbapenem-resistant and colistin-resistant Escherichia coli strain producing NDM-9 and MCR-1 that was recovered from a chicken meat sample.

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Correspondence Emergence of the colistin resistance gene in carbapenem-resistant Enterobacteriaceae

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In The Lancet Infectious Diseases, Yi-Yun Liu and colleagues1 described mcr-1—a plasmid-mediated gene that confers colistin resistance in Escherichia coli and Klebsiella pneumoniae isolates cultured from animals and patients in China. Following this initial finding, several reports2–6 showed that mcr-1 has spread beyond China into south Asia, Europe, Africa, and South America, and into other Enterobacteriaceae species. These reports confirm the finding that the mcr-1 gene is mobilised on plasmids that have spread to different Enterobacteriaceae.

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Correspondence Carbapenem-resistant and colistin-resistant co-producing NDM-9 and MCR-1

dummy_table_thumb.gif

The emergence of plasmid-mediated colistin resistance gene mcr-1 raised great concern that the world was on the cusp of the post-antibiotic era.1,2 Polymyxins, including colistin, are the last-resort antibiotics to treat serious infections caused by carbapenem-resistant Enterobacteriaceae.3 Here, we report a carbapenem-resistant and colistin-resistant Escherichia coli strain producing NDM-9 and MCR-1 that was recovered from a chicken meat sample.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UB4jwp
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Correspondence Emergence of the colistin resistance gene in carbapenem-resistant Enterobacteriaceae

dummy_table_thumb.gif

In The Lancet Infectious Diseases, Yi-Yun Liu and colleagues1 described mcr-1—a plasmid-mediated gene that confers colistin resistance in Escherichia coli and Klebsiella pneumoniae isolates cultured from animals and patients in China. Following this initial finding, several reports2–6 showed that mcr-1 has spread beyond China into south Asia, Europe, Africa, and South America, and into other Enterobacteriaceae species. These reports confirm the finding that the mcr-1 gene is mobilised on plasmids that have spread to different Enterobacteriaceae.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nxTiRu
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process.

Conclusion Decreased expression of Cav-1 and E-cadherin may play an important role in the progression of gastric cancer; Knockdown of Cav-1 may promote EMT of gastric cancer by targeting E-cadherin. PMID: 26817615 [PubMed – as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)

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Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension

Abstract Chondrosarcoma of the faciomaxillary area constitute only 4 % of non-epithelial tumours of the nasal cavity, paranasal sinuses and nasopharynx, making it one of the rare malignancy (Indian J Otolaryngol Head Neck Surg 60(3):284–286, [1]), with its myxoid variety still rarest. It is a slow-growing tumour, occurring mostly in middle-aged men. Primary chondrosarcoma of the nasal and paranasal sinus region, including the nasal septum, rarely extends into the cranial or intracranial areas unless there is recurrence (Indian J Ophthalmol 41(4):189–191, [2]. When it does occur, early diagnosis is difficult because patients generally present with common, nonspecific sinonasal complaints. A 45 year male patient came to ENT OPD with complaints of epistaxis, diplopia, facial sw…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VA0uYH
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process.

Conclusion Decreased expression of Cav-1 and E-cadherin may play an important role in the progression of gastric cancer; Knockdown of Cav-1 may promote EMT of gastric cancer by targeting E-cadherin. PMID: 26817615 [PubMed – as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)

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