Correspondence Carbapenem-resistant and colistin-resistant co-producing NDM-9 and MCR-1

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The emergence of plasmid-mediated colistin resistance gene mcr-1 raised great concern that the world was on the cusp of the post-antibiotic era.1,2 Polymyxins, including colistin, are the last-resort antibiotics to treat serious infections caused by carbapenem-resistant Enterobacteriaceae.3 Here, we report a carbapenem-resistant and colistin-resistant Escherichia coli strain producing NDM-9 and MCR-1 that was recovered from a chicken meat sample.

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Correspondence Emergence of the colistin resistance gene in carbapenem-resistant Enterobacteriaceae

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In The Lancet Infectious Diseases, Yi-Yun Liu and colleagues1 described mcr-1—a plasmid-mediated gene that confers colistin resistance in Escherichia coli and Klebsiella pneumoniae isolates cultured from animals and patients in China. Following this initial finding, several reports2–6 showed that mcr-1 has spread beyond China into south Asia, Europe, Africa, and South America, and into other Enterobacteriaceae species. These reports confirm the finding that the mcr-1 gene is mobilised on plasmids that have spread to different Enterobacteriaceae.

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Correspondence Carbapenem-resistant and colistin-resistant co-producing NDM-9 and MCR-1

dummy_table_thumb.gif

The emergence of plasmid-mediated colistin resistance gene mcr-1 raised great concern that the world was on the cusp of the post-antibiotic era.1,2 Polymyxins, including colistin, are the last-resort antibiotics to treat serious infections caused by carbapenem-resistant Enterobacteriaceae.3 Here, we report a carbapenem-resistant and colistin-resistant Escherichia coli strain producing NDM-9 and MCR-1 that was recovered from a chicken meat sample.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UB4jwp
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Correspondence Emergence of the colistin resistance gene in carbapenem-resistant Enterobacteriaceae

dummy_table_thumb.gif

In The Lancet Infectious Diseases, Yi-Yun Liu and colleagues1 described mcr-1—a plasmid-mediated gene that confers colistin resistance in Escherichia coli and Klebsiella pneumoniae isolates cultured from animals and patients in China. Following this initial finding, several reports2–6 showed that mcr-1 has spread beyond China into south Asia, Europe, Africa, and South America, and into other Enterobacteriaceae species. These reports confirm the finding that the mcr-1 gene is mobilised on plasmids that have spread to different Enterobacteriaceae.

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nxTiRu
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process.

Conclusion Decreased expression of Cav-1 and E-cadherin may play an important role in the progression of gastric cancer; Knockdown of Cav-1 may promote EMT of gastric cancer by targeting E-cadherin. PMID: 26817615 [PubMed – as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)

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via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension

Abstract Chondrosarcoma of the faciomaxillary area constitute only 4 % of non-epithelial tumours of the nasal cavity, paranasal sinuses and nasopharynx, making it one of the rare malignancy (Indian J Otolaryngol Head Neck Surg 60(3):284–286, [1]), with its myxoid variety still rarest. It is a slow-growing tumour, occurring mostly in middle-aged men. Primary chondrosarcoma of the nasal and paranasal sinus region, including the nasal septum, rarely extends into the cranial or intracranial areas unless there is recurrence (Indian J Ophthalmol 41(4):189–191, [2]. When it does occur, early diagnosis is difficult because patients generally present with common, nonspecific sinonasal complaints. A 45 year male patient came to ENT OPD with complaints of epistaxis, diplopia, facial sw…

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VA0uYH
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Decreased Expression of Caveolin-1 and E-Cadherin Correlates with the Clinicopathologic Features of Gastric Cancer and the EMT Process.

Conclusion Decreased expression of Cav-1 and E-cadherin may play an important role in the progression of gastric cancer; Knockdown of Cav-1 may promote EMT of gastric cancer by targeting E-cadherin. PMID: 26817615 [PubMed – as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)

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Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension

Abstract Chondrosarcoma of the faciomaxillary area constitute only 4 % of non-epithelial tumours of the nasal cavity, paranasal sinuses and nasopharynx, making it one of the rare malignancy (Indian J Otolaryngol Head Neck Surg 60(3):284–286, [1]), with its myxoid variety still rarest. It is a slow-growing tumour, occurring mostly in middle-aged men. Primary chondrosarcoma of the nasal and paranasal sinus region, including the nasal septum, rarely extends into the cranial or intracranial areas unless there is recurrence (Indian J Ophthalmol 41(4):189–191, [2]. When it does occur, early diagnosis is difficult because patients generally present with common, nonspecific sinonasal complaints. A 45 year male patient came to ENT OPD with complaints of epistaxis, diplopia, facial sw…

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Biomechanical and biochemical characterization of porcine tracheal cartilage

ConclusionThis study presents a comprehensive characterization of the relevant biochemical and mechanical properties of porcine tracheal cartilage, which is considered an excellent candidate for xenogenic tracheal graft and a source for tissue‐engineered tracheal reconstruction. The range of parameters characterized in this study agrees with those reported for hyaline cartilage of the airway in other species. These characteristics can be used as quantitative benchmarks for tissue‐engineering approaches to treat tracheal disease. Level of EvidenceNA. Laryngoscope, 2015 (Source: The Laryngoscope)

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Upper neck papillary thyroid cancer (UPTC): A new proposed term for the composite of thyroglossal duct cyst‐associated papillary thyroid cancer, pyramidal lobe papillary thyroid cancer, and Delphian node papillary thyroid cancer metastasis

ConclusionThe diagnosis of TGDC cancer comprises a heterogeneous group that includes true TGDC cancer, pyramidal lobe primary, Delphian node metastasis, and indeterminate cases. We propose a new terminology of upper neck papillary thyroid carcinoma (UPTC) to denote this heterogeneous group and recommend a rational algorithm for management. Correct pathologic subcategory and thyroid ultrasonography are essential for optimal management of thyroid gland in UPTC cases. Level of Evidence4. Laryngoscope, 2015 (Source: The Laryngoscope)

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via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174