Meaningful use of Twitter in nursing education may improve student learning and should be considered as a viable educational tool to assist in the development of digital professionalism

Commentary on: JonesRKelseyJNelmesP. Introducing Twitter as an assessed component of the undergraduate nursing curriculum. J Adv Nurs2016;72:1638–53.

Implications for practice and research

Nurse educators should consider incorporating the meaningful use of Twitter into curricula as a mechanism to offer students an interactive and dynamic learning experience related to digital professionalism.

Further research is needed to measure learning outcomes and develop deeper insights towards appropriate pedagogic theories that can be used to underpin social media use in nursing education.

Context

The literature exploring social media in nursing education is growing and suggests there is value in using this online, interactive medium to engage students in a range of topics to enhance learning and develop elements of digital professionalism.12 This study by Jones and colleagues delved into the practicalities of deploying Twitter as an assessed element in an undergraduate nursing programme and discussed various implications for students and…

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Planetary science: Pluto’s telltale heart

Studies of a large frost-filled basin on Pluto show that this feature altered the dwarf planet’s spin axis, driving tectonic activity on its surface, and hint at the presence of a subsurface ocean. See Letters p.86 , p.90 , p.94 & p.97

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Genomic evolution and chemoresistance in germ-cell tumours

Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes. GCTs are histologically heterogeneous and distinctly curable with chemotherapy. Gains of chromosome arm 12p and aneuploidy are nearly universal in GCTs, but specific somatic genomic features driving tumour initiation, chemosensitivity and progression are incompletely characterized. Here, using clinical whole-exome and transcriptome sequencing of precursor, primary (testicular and mediastinal) and chemoresistant metastatic human GCTs, we show that the primary somatic feature of GCTs is highly recurrent chromosome arm level amplifications and reciprocal deletions (reciprocal loss of heterozygosity), variations that are significantly enriched in GCTs compared to 19 other cancer types. These tumours also acquire KRAS mutations during the development from precursor to primary disease, and primary testicular GCTs (TGCTs) are uniformly wild type for TP53. In addition, by functional measurement of apoptotic signalling (BH3 profiling) of fresh tumour and adjacent tissue, we find that primary TGCTs have high mitochondrial priming that facilitates chemotherapy-induced apoptosis. Finally, by phylogenetic analysis of serial TGCTs that emerge with chemotherapy resistance, we show how TGCTs gain additional reciprocal loss of heterozygosity and that this is associated with loss of pluripotency markers (NANOG and POU5F1) in chemoresistant teratomas or transformed carcinomas. Our results demonstrate the distinct genomic features underlying the origins of this disease and associated with the chemosensitivity phenotype, as well as the rare progression to chemoresistance. These results identify the convergence of cancer genomics, mitochondrial priming and GCT evolution, and may provide insights into chemosensitivity and resistance in other cancers.

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Cell biology: Sort of unexpected

To reach the cell surface, membrane proteins are first targeted to an organelle called the endoplasmic reticulum. Several targeting pathways are known, but it now emerges that there is yet another pathway. See Letter p.134

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