Shifting the optimal stiffness for cell migration
Nature Communications, Published online: 22 May 2017; doi:10.1038/ncomms15313
Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.
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