Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
Nature Communications, Published online: 22 May 2017; doi:10.1038/ncomms15363
DNA degradation products are frequently found in the endosome, but how they regulate the activation of Toll-like receptors is not known. Here the authors show that single-stranded DNA as short as two nucleotides can enhance the ability of longer DNA oligonucleotides to activate Toll-like receptors.
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