Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
Nature Communications, Published online: 12 June 2017; doi:10.1038/ncomms15817
Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow, and identify zyxin as a regulator of stress fibre mechanics and homeostasis.
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