The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites
Nature Communications, Published online: 12 June 2017; doi:10.1038/ncomms15751
The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
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